Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans
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The Pathogen Candida albicans Hijacks Pyroptosis for Escape from Macrophages
The fungal pathogen Candida albicans causes macrophage death and escapes, but the molecular mechanisms remained unknown. Here we used live-cell imaging to monitor the interaction of C. albicans with macrophages and show that C. albicans kills macrophages in two temporally and mechanistically distinct phases. Early upon phagocytosis, C. albicans triggers pyroptosis, a proinflammatory macrophage ...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2020
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1008328